Pregabalin (PGB) kev kuaj nrawm nrawm

Pregabalin, muag hauv lub npe lag luam Lyrics^®, ib qho piv ntawm inibitory Neurotransmetter gamma-aminobutyric acid thiab kuj tau siv tshuaj ntsuam, anticonvulsant thiab kev ntxhov siab tus neeg sawv cev. Nws yog muab rau raws li cov tshuaj dawb hauv 25-300 mg cyrsules rau kev tswj hwm qhov ncauj. Cov neeg laus tau ib txwm muaj feem ntau nyob hauv ib qho ntawm 50-200 mg thiav txhua hnub.
Ib qho ntawm ob lub qhov ncauj sau tseg cov koob tshuaj ntawm cov tib neeg tau tshem tawm hauv cov zis (92%) thiab quav (<0.1%) over a 4 days period. Urinary excretion products included unchanged drug (90% of the dose), N-Methylpregabalin (0.9%) and others. Single oral 75 or 150mg doses given to a healthy human yielded peak urinary pregabalin concentrations of 151 or 214 μg/mL, respectively, in the first 8 hours specimen. Pregabalin urine levels in 57,542 specimens from chronic pain patients averaged 184 μg/mL